Foldit is an online video game that challenges players to fold various proteins into shapes where they are stable. Generally, folding proteins allows scientists (and citizens) to design new proteins from scratch, but in the case of coronavirus, Foldit players are trying to design the drugs to combat it. “Coronavirus has a ‘spike’ protein that it uses to recognize human cells,” says Brian Koepnick, a biochemist and researcher with the University of Washington’s Institute for Protein Design who has been using Foldit for protein research for six years. “Foldit players are designing new protein drugs that can bind to the COVID spike and block this recognition, [which could] potentially stop the virus from infecting more cells in an individual who has already been exposed to the virus.”
“In Foldit, you change the shape of a protein model to optimize your score. This score is actually a sophisticated calculation of the fold’s potential energy,” says Koepnick, adding that professional researchers use an identical score function in their work. “The coronavirus puzzles are set up such that high-scoring models have a better chance of actually binding to the target spike protein.” Ultimately, high-scoring solutions are analyzed by researchers and considered for real-world use….(More)”.