Editorial by Suzanne Bakken: “In this editorial, I highlight 5 papers that address innovative informatics interventions—3 research studies and 2 reviews. The papers reflect a variety of information technologies and processes including mobile health (mHealth), behavioral nudges in the electronic health record (EHR), adaptive intervention framework, predictive models, and artificial intelligence (eg, machine learning, data mining, natural language processing). The interventions were designed to address important clinical and public health problems such as adherence to antiretroviral therapy for persons living with HIV (PLWH), opioid use disorder, and pain assessment and management, as well as aspects of healthcare quality including no-show rates for appointments and erroneous decisions, waste, and misuse of resources due to EHR choice architecture for clinician orders…(More)”.