The tricky math of lifting coronavirus lockdowns


James Temple at MIT Technology Review: “…A crucial point of the work—which Steinhardt and MIT’s Andrew Ilyas​ wrote up in a draft paper that hasn’t yet been published or peer-reviewed—is that communities need to get much better at tracking infections. “With the data we currently have, we actually just don’t know what the level of safe mobility is,” Steinhardt says. “We need much better mechanisms for tracking prevalence in order to do any of this safely.”

The analysis relies on other noisy and less-than-optimal measurements as well, including using hospitalization admissions and deaths to estimate disease prevalence before the lockdowns. They also had to make informed assumptions, which others might disagree with, about how much shelter-in-place rules have altered the spread of the disease. Much of the overall uncertainty is due to the spottiness of testing to date. If case counts are rising, but so is testing, it’s difficult to decipher whether infections are still increasing or a greater proportion of infected people are being evaluated.

This produces some confusing results in the study for any policymaker looking for clear direction. Notably, in Los Angeles, the estimated growth rate of the disease since the shelter-in-place order went into effect ranges from negative to positive. This suggests either that the city could start loosening restrictions or that it needs to tighten them further.

Ultimately, the researchers stress that communities need to build up disease surveillance measures to reduce this uncertainty, and strike an appropriate balance between reopening the economy and minimizing public health risks.

They propose several ways to do so, including conducting virological testing on a random sample of some 20,000 people per day in a given area; setting up wide-scale online surveys that ask people to report potential symptoms, similar to what Carnegie Mellon researchers are doing through efforts with both Facebook and Google; and potentially testing for the prevalence of viral material in wastewater, a technique that has “sounded the alarm” on polio outbreaks in the past.

A team of researchers affiliated with MIT, Harvard, and startup Biobot Analytics recently analyzed water samples from a Massachusetts treatment facility, and detected levels of the coronavirus that were “significantly higher” than expected on the basis of confirmed cases in the state, according to a non-peer-reviewed paper released earlier this month….(More)”.