Irreproducibility is not a sign of failure, but an inspiration for fresh ideas

Editorial at Nature: “Everyone’s talking about reproducibility — or at least they are in the biomedical and social sciences. The past decade has seen a growing recognition that results must be independently replicated before they can be accepted as true.

A focus on reproducibility is necessary in the physical sciences, too — an issue explored in this month’s Nature Physics, in which two metrologists argue that reproducibility should be viewed through a different lens. When results in the science of measurement cannot be reproduced, argue Martin Milton and Antonio Possolo, it’s a sign of the scientific method at work — and an opportunity to promote public awareness of the research process (M. J. T. Milton and A. Possolo Nature Phys26, 117–119; 2020)….

However, despite numerous experiments spanning three centuries, the precise value of G remains uncertain. The root of the uncertainty is not fully understood: it could be due to undiscovered errors in how the value is being measured; or it could indicate the need for new physics. One scenario being explored is that G could even vary over time, in which case scientists might have to revise their view that it has a fixed value.

If that were to happen — although physicists think it unlikely — it would be a good example of non-reproduced data being subjected to the scientific process: experimental results questioning a long-held theory, or pointing to the existence of another theory altogether.

Questions in biomedicine and in the social sciences do not reduce so cleanly to the determination of a fundamental constant of nature. Compared with metrology, experiments to reproduce results in fields such as cancer biology are likely to include many more sources of variability, which are fiendishly hard to control for.

But metrology reminds us that when researchers attempt to reproduce the results of experiments, they do so using a set of agreed — and highly precise — experimental standards, known in the measurement field as metrological traceability. It is this aspect, the authors contend, that helps to build trust and confidence in the research process….(More)”.